Clean it Up
Giving your laptop (or desktop) a thorough cleaning is essential to extending its life. Back up any data you may already have stored (on an external hard drive or portable flash drive), organize your desktop icons, empty your computer's trash on a regular basis, and clear out any programs you don't use. This will help free up space and keep you on the fast track to productivity.
Practice proper shut-down habits
Shutting down all open programs, and putting your laptop to sleep instead of just closing the lid will help your computer stay cool and safe while in transport.
Protect your investment
If you're going to be lugging a laptop around campus, make sure it's protected in a padded case!
See the rest of my tips after the jump.